Little update on my situation.
I pretty much deactivated everything. Then I created a .txt in which I'm keeping a journal of what I install when, about how much playing I do at each additional step in adding mods one by one, what game functions I perform (e.g., used F4, used Esc-Save, used Shift- and Ctrl- in TQP, etc.).
One thing different from my past efforts. After activating a mod in OBMM, I then run BOSS (not new) and then also run TES4Edit. I'm not sure if just running helps in anyway, but anyway that is what I have been doing. I'm not really looking at conflicts and then doing anything (don't see any reds, though I'm not exhaustively going through every sub-entry).
So far, I've reinstalled the following load order, and have had no more problems apart from a couple spontaneous CTDs from going into the Map (F4) window while I was wrapping up the Unfriendly Competition Quest (must've been the quest markers were slow in updating, cause no problems since).
Spoiler Oblivion.esm
Unofficial Oblivion Patch.esp
DLCShiveringIsles.esp
Enhanced Economy.esp
Thieves Arsenal.esp
Knights.esp
Harvest [Flora].esp
Harvest [Flora] - Shivering Isles.esp
Bag of Holding.esp
DropLitTorchOBSE.esp
P1DkeyChain.esp
Toggleable Quantity Prompt.esp
Let There Be Darkness - Cyrodiil + SI.esp
Let There Be Darkness - Knights.esp
So from the set I have created as OMODs and which I would ideally like to be able to use I have yet to install:
Map Marker Overhaul
Alchemy Advanced
Spell Delete & Item Remove
MD Saddle Bags
HungryThirstySleepyTired 1.0
The Lost Spires
The only one of those whose functionality I deem to be very important for me is the HungryThirstySleepyTired.
Without a mechanism to force me not to run all the time, to eat and sleep and drink, I just go into superhero-mode and roleplaying is out the door. I knew this from playing FO3, and noticing how much of an improvement a Basic Needs mod made for me with that game.
However, since the game is now running well, I'm going to hold off a bit and see if I can figure out an alternative to Tyler's mod. I think I will start a thread that specifically asks about this sort of mod; my searches on TES Nexus make me think the Tyler mod is the most up-to-date and best one available.