Cassandra, the NCR leader in hoover dam, will no longer talk to me after dealing with the Omertas. I followed the plot to change the leadership around, but after killing Big Sal and his buddy, her dialogue won't start. By "won't start," I mean the camera goes to zoom in and talk, then just zooms back out without a peep. Then it gets all weird, my character vanishes, and I have to reload a previous save to fix it.
I also crash relentlessly at loading screens. It goes black, I lose the music, and just have to restart my console. It's so common that I've begun keeping two saves, and just saving right before I know a loading screen is coming. I hardly ever froze before the patch. Here and there, maybe twice on a play-through. I know other people's experiences with that have been very different, so maybe I was lucky.