I have this issue as well. I also get the same crash If I go slightly past the BADTFL regional office if you're walking from the place with the obelisk (I forget the name). I've tried updating drivers, clearing ini files, reinstalling both on an ssd and a normal hard drive and everything else under the sun If it had an error message it would make it much easier. This makes two entire questlines unable to be completed. My specs are
Win 10
8gb dual channel DDR3 @ 666MHz Ram
EVGA 970
Intel Core I5 4670K
Gigabyte Z97-D3H-CF mothervboard
I've only used one console command and it was to increase carryweight which I undid a little bit after (was testing some stuff).