Here is a great example of how not to do it:
http://ca.gizmodo.com/5812227/idiot-uses-shotgun-to-remove-wart-from-his-finger

Well, hey- it worked! Can't argue with success, eh wot?

Went to high school with a kid that blew off part of his middle finger with a shotgun he had it over the muzzle and pulled the trigger we called him nubby.

To bad NV isn't like SoF which you can amputate people while not kill them.

He also took http://fallout.wikia.com/wiki/Jinxed