I mean, yes it can be annoying when you lose a quest item, but honestly, it's your fault if you lose it. No one MAKES you sell it. I mean, half the quest items you find in the F3-F:NV generation have unique names or pipboy icons, so it makes sense you should hang on to it, or put it somewhere safe. If you sell it or lose it and render a quest uncompletable, then it should fall on your head.
What are your opinions?