It's basically confirmed because:
-SPECIAL stats no longer list the skills they increase. You may think "that doesn't neccesarily mean anything," but Intelligence in particular now effects experienced gained and lost it's trademark skill-points-per-level-up ability.
-There is no skills tab in the stats menu of the Pipboy
-Science is now a ranked system, like a perk or something
-Weapon and armor degradation are missing, meaning repair can't really exist