I'm interested to see more before I pass judgement on whatever the new system is. I guess the discussion has been moving quickly since the title of this thread is Discussion 2 (didn't even see the first one), so this has probably already been said, but this is what I saw:
There is no Skills tab in the Pipboy, just Status, SPECIAL, and Perks. Skills still exist in some way, since the crafting screen showed prerequisites like Science rank 1 and Science rank 2. I wonder how many of the old skills have been rolled into the Perk tree? I wonder how many ranks there are for things like Science, Lockpick, or Repair?
Todd mentioned Mysterious Stranger, so some of the old Perks still exist along side the skill-perks. I guess at each level-up we'll be balancing our points between ranking up skills and choosing more unique abilities. I wondered if the unique perks unlock with ranks of the skill-perks, but I think that would homogenize peoples builds too much, so I hope that's not how it works. More likely some of the unique perks will have skill-perk rank prerequisites.
It's also possible that we level skills through a "learn by doing" system like Skyrim, and those skills become prerequisites for the perk tree. If this is the case, I wonder why there's no Skills tab in the Pipboy, but maybe they just show in the Perks tab.