Skyrim will probably get
a game of the year, somewhere. Regardless, competition's going to be stiff. As far as RPGs go,
Mass Effect 3 is the biggest contender.
Guild Wars 2 could be the show-stealer as well, assuming it comes out this year. And both
The Witcher 2 and
Dark Souls could end up as surprise hits.
It's going to have some serious competition with Mass Effect 3, the Witcher 2, and as much as I loathe to say it probably Dragon Age 2 as well.
Eh, I don't think DA2 has a chance. Whatever its quality is going to be, ME3 will inevitably steal its thunder.