We still need specs but more importantly we might need dxdiag.exe to be run and posted into spoiler tags since that can give us a lot of information can be told by that such as driver issues and such.
Also a listing of mods and the load order would be nice.
Also it is not a good idea to disable mods with a current character since mods quite often have data that remains on the game save and could cause game save corruption.
Also it is a good idea to disable the autosave feature and make a fresh game save on a regular basis and try not to overwrite game saves, since that is known to cause game save corruption.
Do you use a mod manager to install mods and do you use loot to sort the load order.