Try these NVIDIA Inspector settings, guys, straight from the Data Vault thread:
Open http://www.guru3d.com/files-details/nvidia-inspector-download.html, click on the http://imgur.com/a1oup2f, then in the newly opened window search for Fallout 4 from the http://imgur.com/EAj0pAI and configure the settings bellow as follows:
SLI compatibility bits (DX1x): 0x080202F5 (Batman: Arkham City)
SLI compatibility bits: 0x00000000
Multi-display/mixed-GPU acceleration: Single display performance mode
Number of GPUs to use on SLI rendering mode: SLI_GPU_COUNT_TWO
NVIDIA predefined number of GPUs to use on SLI rendering mode on DirectX 10: SLI_PREDEFINED_GPU_COUNT_DX10_TWO
NVIDIA predefined number of GPUs to use on SLI rendering mode: SLI_PREDEFINED_GPU_COUNT_TWO
SLI rendering mode: SLI_RENDERING_MODE_AUTOSELECT
Remember to click on the "Apply changes" button in the top-left corner and you are good to go! Please let me know if these work well for you as well, since http://www.gamesas.com/topic/1543988-a-data-vault-of-tweaks-and-fixes-for-the-pc-version/page-7#entry24528684 has nothing but praise for them.