I've just returned to Oblivion after a few months break and I started a new character. So far it's great fun but I'm having some minor problems.

First off, the "activate/pickup" button is simply slow. I found multiple coins on a table in a dungeon and tried to pick them up quickly by rapidly pressing "E" on my keyboard. Before it's been picked up very quickly but now, once I had picked up the first, the "E" button did not respond for about a second, after which I could pick up the next item. It seems to need a breather, which has not occured before. Help?

And second, I play a character which uses both bow and blade. I have bound the weapons to different hotkeys, but there is some trouble here as well. E.g, if I have the sword equipped (hotkey 4) and press 3 to equip the bow, it starts clipping. The bow might show up for half a second, after which it is unequiped, leaving me without any weapon at all. If I try again, the same thing happens. Shown for half a second, then vanishes back into the inventory. Sometimes it works, but mostly not. Any ideas?

Yes, I'm running dozens of mods.

Post your load list.

Ah, thanks HeyYou. Problem solved though. I deactivated tons of mods I didn't want/need and now it seems to work fine.

EDIT: Still random crashes once in a while, but it's getting better. Maybe someone could help with that.

Oblivion.esm
MathFunctions.esm
TamrielTravellers.esm
Kvatch Rebuilt.esm
Better Cities Resources.esm
cssBase.esm
CM Partners.esm
MERP Data.esm
Oblivifall Master File.esm
ShieldOnBack.esm
Unofficial Oblivion Patch.esp
DLCShiveringIsles.esp
Unofficial Shivering Isles Patch.esp
MOBS SI.esp
Better Cities .esp
Natural_Habitat_by_Max_Tael.esp
Natural_Water_by_Max_Tael.esp
Bedrollsanyone.esp
ClocksOfCyrodiil_BC_OBC_OC_OCLR_Vanilla.esp
RAEVWD Cities.esp
RAEVWD New Sheoth.esp
RAEVWD Imperial City.esp
Spell Delete And Item Remove.esp
Crowded Roads Revisited.esp
Improved Hotkeys.esp
DLCHorseArmor.esp
DLCHorseArmor - Unofficial Patch.esp
DLCOrrery.esp
DLCOrrery - Unofficial Patch.esp
DLCVileLair.esp
DLCVileLair - Unofficial Patch.esp
DLCMehrunesRazor.esp
DLCMehrunesRazor - Unofficial Patch.esp
MaleBodyReplacerV4.esp
Adonnays Elven Weaponry.esp
DMRangerArmor.esp
XSPipeMod.esp
cidnothump.esp
DLCThievesDen.esp
DLCThievesDen - Unofficial Patch.esp
DLCThievesDen - Unofficial Patch - SSSB.esp
TamrielTravellerAdvscript.esp
TamrielTravellers.esp
TamrielTravellersFactionAll.esp
TamrielTravellersItemsVendor.esp
ShiveringIsleTravellersFriendlyFactions.esp
Ivellon.esp
BravilSeaDomes.esp
FenrirTheWolf.esp
Kvatch Rebuilt.esp
LetThePeopleDrink.esp
LostSwordOfTheAylied.esp
LostSwordOfTheAylied - OBSE Add-On.esp
MountainShack.esp
Solace.esp
TOTW.esp
TOTWfurn.esp
TOTWcamp.esp
Villages1.1.esp
WOTFH_1.3.esp
DLCBattlehornCastle.esp
DLCBattlehornCastle - Unofficial Patch.esp
BattlehornCastleEnhanced.esp
DLCFrostcrag.esp
DLCFrostcrag - Unofficial Patch.esp
Knights.esp
Knights - Unofficial Patch.esp
Castle_Knightstone.esp
RTT.esp
The Lost Spires.esp
ElsweyrAnequina.esp
Natural_Vegetation_by_Max_Tael.esp
DecoratorAssistant with OBSE v1.1.esp
Kyoma's Journal Mod.esp
Quest Award Leveller.esp
Quest Award Leveller - Vile Lair.esp
Quest Award Leveller - Mehrunes Razor.esp
Quest Award Leveller - Knights of the Nine.esp
Kobu's Skip Intro Mod.esp
Disenchant.esp
Faster Spells.esp
Enchantment Enhanced.esp
Better Enchanting & Spellmaking Readme.esp
Denock Arrows.esp
_Ren_BeautyPack_full.esp
CM Partners.esp
CM Partners Special NPCs.esp
CM Partners NPC.esp
CM Partners More NPCs.esp
CM Partners Marker NPCs.esp
CM Partners Extra NPCs.esp
cssCalisto.esp
bgBalancingEVCore.esp
bgMagicEV.esp
bgMagicSpellTomes_for_WryeBash.esp
bgMagicItemSigil.esp
bgMagicBonus.esp
bgMagicEVAddEnVar.esp
bgMagicEVPaperChase.esp
bgMagicAlchemy.esp
bgBalancingEVOptionalClasses.esp
bgIntegrationEV.esp
Better Cities - Full City Defences.esp
Better Cities SKINGRAD.esp
Better Cities BRAVIL.esp
Better Cities ANVIL.esp
Better Cities - Ruined Tail's Tale.esp
Better Cities CHORROL.esp
Better Cities CHEYDINHAL.esp
Better Cities LEYAWIIN.esp
Better Cities - No LEYAWIIN Flooding.esp
Better Cities BRUMA.esp
bgMagicEVShader.esp
bgMagicShaderLifeDetect.esp
bgMagicLightningbolt.esp
Viconia.esp
Duke Patricks - BASIC Script Effect Silencer.esp
Abriael_Human.esp
Encumbrance100.esp
CT-Backpacks.esp
ShieldOnBack_1C.esp
Alternate Script Effect Icon.esp
Visually Enchanted Paralyze by Agesofb.esp
ClaimThatInterior.esp
Arch_Mages_Robe_Enchanted-2185.esp
TheOubliette.esp
Vypers Arrow Spells-SI V2.esp
passive_wildlife-1945.esp
TTB.esp
Banes DB Mask Placer True.esp
fwDropGold.esp
1HweaponOnBack.esp
Universal_Armor_Stands.esp
Wood Bows and Leather Armors.esp
Walkabout.esp
Oblivifall - Losing My Religion.esp
VyperSMETG.esp
AzuraStarfix.esp
SigilStoneSelector.esp

Sorry, but... bump.

Really need help with this.
The crashes are always when I fast-travel, never otherwise.

When you fast travel to a specific location? or, just when you fast travel at all??

Any fast travel, it seems, whether it be to a cave, a city, a camp, anything really.

May have happened some time when I passed through a door or gate as well, but not quite sure. Maybe it's on loading screens it happens, not just fast travel.

Can you do interior/exterior changes okay?

I've played some more and yep - it seems I can do transitions fine. In fact, I can play normally for maybe half an hour - it's when I fast travel after that time that it occasionally crashes.

Do you have autosaves turned on?

Yep. Also, when saving manually, I always overwrite the last save. I seem to recall this may lead to crashes, but perhaps I am wrong?

Yes, it can.... autosaves, quicksaves, and overwriting saves are all dangerous.......

Hm, I'll try to refrain from overwriting then, and see how it goes. I'd like to keep autosave for the moment though, it has saved me many a time. Thanks!

I used to get a lot of CTD, travelling and otherwise. If you don't have it already then get the obse plugin Crash prenvention
http://www.tesnexus.com/downloads/file.php?id=22282
It has worked very well for myself might do you some good to