Being unable to alter the controls.
When a sequels game mechanics are changed so much that things I miss in the original are lost.
When it comes to MMORPGs every character/weaponc/class/etc/ becoming so nerfed due to reasons related to PvP, that past the games birth, an originally very diverse game, ends up with everything far more homogenized. Other than Planetside 2, I avoid MMORPGs with heavy PvP for that reason, I like faction based PvP, but I also don't like constantly worrying about a highly beloved playstyle being forever removed from the game, due to what I just explained.
Being forced to play as either, squishy wizard, classic tank, or sneaky magically inept sneaky type, with no other options.
Lack of customization of character stats, and lack of customization of character appearance, but if the game is good enough in every other way this can be overlooked.
When a sequel has technologically superior graphics, but less diverse, and less otherworldly art.
Cheesy stereotypical romance plots, same applies to movies really.
Being forced to play as a human, especially one that isn't a cyborg or can't transform or anything... Although this is a much smaller issue than the other things that I can easily tolerate if the game is good enough.
Plots revolving around "That one human faction", "that one entirely united vampire faction", "that one entirely united werewolf faction", "that one entirely united alien faction", and "that one entirely united robot faction", with no signs of infighting, or more closely knit subgroups fighting amongst each other.
Also games where humans are good and whoever they fight is evil, and you have to side with the humans in it.
Games overusing the sword in it's top melee weapon categories, I can grudgingly tolerate this but it's jarring.
Games that universally portray orcs as evil.
Games that universally portray cyborgs as evil.
Games that have stereotypical villains mostly clad in black, and covered in spikes, with lava castles and the like.
The other overused trope, of the big brawny warrior who never uses stealth or magic, and somehow the magic users, and sneaky characters being inclined to be evil, or in scifi games/storylines scientists repeatedly being portrayed as evil, while the hero character is almost always some type of soldier or warrior.
Overtly used tropes in generally, and linear gameplay.