This is so weird, and only just started. I have a modded Tactical Sniper Rifle. It's my go-to weapon for scouting and sniping. Suddenly today, it stops being able to fire while zoomed. When I first load a fresh save, ican fire a single shot while scoped, then suddenly, I can scope, but I can't fire. I can fire from the hip. I can use iron sights on my non scoped guns and fire without issue. The problem appears to be only with scopes.

Your talking a nexus mod? If so, try taking the mod off and see what happens.

I meant modded as in weapon mods. I don't have any mods that affect scopes or guns or anything like that. In fact, I removed the only one (Lowered Weapons) that even touched it, but no one else has this problem after removing it.

Hmm, have you tried verifying your game files? I'm kind of at a loss since it isn't a third party type of mod. I personally don't use those types of mods but I have heard sometimes people have problems with them. Sorry i couldn't help. gl

Okay, I've verified the files (repaired 4), and reinstalled the Lowered Weapons mod on the off chance removing it was the problem.

Nope, problem continues. I'm completely at a loss. I'm a bloody Sniper build. If I can't SNIPE, then this character is seriously gimped.