Not sure if someone has brought this up yet but is haven't seen it as of recent, so basically you are the sole survivor of your vault but what about your wife/husband and baby? What happened when the bombs fell? Was your character only one of 3 to make it in? Could your spouse and baby have left earlier and reside in the wasteland (assuming the cryogenics rumor holds true making this possible) or did they simply die in the vault or during the war? If so what purpose or relavence did making a baby designed after the parents hold?
We don't know just yet, they didn't elaborate on anything more specific. They'll release more details in the coming months, but I wouldn't expect to get all of those questions answered until release day.
Oh of course something that ties into the storyline we won't truly find out till at least few minutes into the storyline of our own play through , I assume Bethesda will be as tight lipped about storyline as they were at e3 but I am curious about other people's idea behind the mysterious start after you leave vault 111.