I'm going to list a few bugs I've found and would really like patched...

1. Train Tunnel Hole... Please fix this I really wanna see whats in there
2. Dropped Items like to disappear inside my Brotherhood Safehouse
3. Followers can crippled but only uncrippled by being killed
4. Ed-e likes to get stuck in ceilings and door frames which leads to him disappearing
5. These items cannot be dropped even when quests are finished or you don't know what quest they are for.
- Motor-Heads Helmet
- Container of Chlorine
- Distinctive Cigarette Butt
- Engraved Cigarette Lighter
- Howitzer Firing Mechanism
- Legion Patrol Notes
- Legion Raid Plans
- Lottery Tickets
- Marked Cards
- NCR computer parts
- NCR Radio Parts
- Rey's Brain
- Rocket Souvenir
6. Some items fall directly to the floor and glitch into it when dropped.
- Marked Cards
- Some guys journal 2/2
- Lottery Tickets
- Shells .308
- Shells .44

I'll add more when I find them.