Need to know which version of the CS you are running, version of the game you have, where it is installed, and the exact error message you are getting when trying to save, and failing....... Operating system would be good too....
if you start a NEW esp file, can you save that one? (and then open it up, and save again later?)
Let's see what I can find.....
Computer OS is: Windows XP Professional 2002 version.
For Elder Scrolls IV: Oblivion, this is the path file: C:\Program Files\Steam\steamapps\common\oblivion
For it, I purchased whatever the latest upgrade was at the time, and that wasn't long ago either. A few months at most.
For the TES Construction set, it's apparently to the same file folder as Oblivion, by the looks of things. Hmmm.... can't seem to find out which version it is. (tried going to Properties for it, and I didn't see it there.)