There are some games that just not play well together, or played at the same time. Hot a key for game and it does one thing. Hit the same key in another game and it does something completely different

Using Bethesda games for examples, I can not play Morrowind and Skyrim close to each other. Right click in Morrowind opens inventory/character sheet while it blocks in Skyrim. Space bar activates objects in Morrowind and Jumps in Skyrim. Luckily, I can reprogram the keys to better match each other, but there are still some subtle differences

Then I tried playing Skyrim after a few months in the Fallout 3 and New Vegas universe. Ho, boy! Fallout uses the "A" key to loot all while Skyrim uses the "R" key. Fallout uses to open the inventory (PipBoy) and Skyrim uses the "I" key. I found myself trying to recall how to get to my "Quest Log" ("J" key) ion Skyrim

These games have kept me on my toes, though. No accidental bashing of an NPC while trying to open my inventory has occurred yet

Have you found other games that do not "play well together?"

I know what you mean. I play on the X1 and when I finish a game and start a new one it takes me a couple of days to get used to which buttons do what again, attack and action buttons being different etc.