HUD can be disabled! You can remove everything even crosshairs.
3rd person view finishing moves can be disabled!
When you pick plants they actually are removed from the environment
Alchemy can no longer be performed anywhere, only at work stations or laboratorys.
And finally speechcrafting has had some bigger changes. More like fallout 3. The conversation branches off.
So thats what I got. Hope it answers some questions for people.
Link. http://www.gameranx.com/updates/id/3001/article/skyrim-allows-you-to-hide-ui-features-new-speechcraft-system/