This will be the continually updated list of problems, glitches, and bugs I've had so far;
1. Invisible item: Pint Glass. Some may think that I'm just not looking directly at it, so I only think it's invisible. But I've actually psychokinetically picked on up, as you do in the BethS games, and I could vaguely see a sorta silhouette when you place it over a distant light source.
2. Disappearing Pies: Self descriptive. I spend a good amount of time just sitting next to a Port-A-Diner to get it's Perfectly Preserved Pie for my Pie collection, and recently, out of the 4 times I've decided to try and get it, twice the pie didn't appear in the slot.
3. Omniscient AI: This mostly regards to sneaking. Whenever I'm sneaking and land a shot or kill an enemy that leads to others going on alert, those who want to find me seem to have this latency to know my general direction, and not just with the shot. If I place a live grenade on someone and sneak off without being noticed, the AI searching for me will follow me where I'm going. I've shot a Glowing Deathclaw once in the back, and it followed me exactly where I went for a good 40 paces in an S pattern before it readjusted to attack the 6 supermutants shooting it.
4. Non-despawning weapons and Power Armor: Self descriptive. I've stole a few power cores from Brotherhood patrols, so that get out of the armor and then be easier to kill, but the power armor just stays there. I've just started collecting/stealing the armor so as to get them out of the way. The same goes for weapons. Every time I kill an enemy but don't want their weapon, it'd just stay on the ground, even after the body despawned. I've started collecting the weapons too, as to get them out of the way.
5. Defend the Castle: After choosing to shoot down the Prydwen as the Minutemen, the mission Defend the Castle starts, and you're tasked to survive 10 waves of Vertibirds. For one, one one occasion, one of the vertibirds clipped thru the ground and couldn't be destroyed. Multiple times the game had froze for me on this mission. And then the major problem is my inability to talk to Ronnie Shaw to finish it. Every time I get near her, my character either chooses to ask to trade gear, or to shop, and any deliberate interaction just has my character asking to trade gear.
6. Nonstop questions about our relationship: I've had multiple interactions with different companions that I've reached max affection with where they continually ask me, again and again, about the personal conversation we had, and no matter how many times I thank them for their trust, ask to keep it personal, and even test the waters of the relationship branch then tell them I don't love them, or that I still love my wife, they still keep asking about our potential relationship/ the personal conversation.