#2: Post processing screws up Crossfire performance. Get rid of it using a custom CFG. (I gained 10fps)
#3: Windowed mode only uses 1 GPU
#4: Crossfire perfomance seems to gradually degrade over time while playing the game. To fix this - press alt+enter (to switch to single-GPU mode) and then alt+enter again to return to fullscreen mode. You should see a big gain in the before/after crossfire perfomance.
For example: I notice my FPS is a little low, say ~45. I perform the above method, with a resulting FPS of ~60.
I don't know why this happens; It's not as severe as a memory leak (although it could be a minor one), or if the above method only works for me.
Try it out; If it does work, create some buzz so the devs notice.