I don't know if this is true but it seems to be. In my 1 day playing streak I noticed the load times started to get worse and worse. Sometimes taking up to 2 mins+ to load a place. I shut down the xbox reloaded the game and load times improved quite a bit. I've done this several times and it seems to do the trick.

I have about 20 saves as well.

I noticed the same thing. I've found that, after and hour or two, it's a good idea to go back to the Dashboard and relaunch the game. I guess this is evidence of a memory leak? Anyway, it seems to work for me when the load times start to take more than a couple seconds.

Perhaps a patch. I mean the load times can be pretty insane. Especially if you are loading a huge area like freeside. At least I'm not crazy. Anyone else notice this.

http://www.gamesas.com/index.php?/forum/113-fallout-new-vegas-xbox-360-issues/...

Maybe after playing for so long its memory just gets bogged down, and restarting it all clears the cache?