If there was a quest to collect parts for the robot you'd at least get the sense you were seeing a payoff for your actions in the big cutscene battle.

The fact that I can't run NMC's texture pack without crashing.

Real shame. The mod does wonders for the game. It just looks amazing.

Same thing that bothers me about Skyrim, they recycle voice actors for way too many characters. There also doesn't seem to be much recognition of your accomplishments aside from Three Dog announcements and karma ratings with some NPC's.

Stealth approach could have been better implemented. I just finished Rescue From Paradise quest and it seems almost impossible to keep Rory alive playng legit. I know it can be done, but it seems like a lost cause. I used a stealthboy and wore a shady hat with a decent amount of sneak points, yet everytime I tried to mez the guard with the minigun, I got caught. I finally gave up on trying to keep Rory alive and just ended the quest.

More ways to complete quests. The Nuka Cola Challenge quest for example. Why can't I just give or sell the Nuka Cola formula to Siearra as a substitute instead of scavenging the wasteland for 30 bottles of Quantum cola? Any addict would gladly take a recipe to satisfy their own addiction. A way to overthrow Paradise Falls with former slaves and enslave Eulogy and his minions.

All that technology like a G.E.C.K. and no cell phones?

Last but not least, the usual Bethesda glitches like random freezing gets annoying.