I had my best experience so far with a brand new character. It happened completely by accident. I took the character all the way through the vault beginning and made my usual save in front of the exit. Then I started playing Neverwinter with a friend for several weeks. When I returned to my character, still in front of the exit, the memory of the vault was so faded that I was able to ignore it. I'm now roleplaying a character who has never been inside a vault.
It's still tough though. The game continues to give my character dialogue about finding her father. *sigh*