There were news of upcoming update to Fallout 4 Survival difficulty some time ago, bringing more immersive experience of adventuring in the post apocalyptic wasteland.
While most of the changes (like fatigue, hunger, ammo weight etc.) sound great, I'm not really into "Manual and quicksaving are disabled. To save your game, you'll need to find a bed and sleep for at least an hour." part.
"No saving" policy works great when the game in question is initially built with this mechanic in mind. Like in XCOM and Darkest Dungeon, even if your party gets wiped, you can still carry on without loosing global progress and upgrades, or in Dark Souls save/load is naturally blended into the gameplay and narrative: you always have a chance to reclaim your lost souls and you don't loose items.
In Fallout 4 on the other hand if i die at the end of a quest like Reunions, then i just completely lost an hour of progress. Stepped on the mine? PC/game crashed? Time lost. Players can obviously sleep every 5 minutes, but that's just kills the immersion. I will gladly use sleep when my character is tired rather than sleep every time i'm about to enter some dangerous area like i'm having excessive sleepiness disorder.
My point is that removing some initial game mechanic like saving requires addition of something to compensate (e.g. failure or death doesn't equal game over). Otherwise it's better to leave the decision whether to save or not to players.