I'm seriously considering a full Strength/Endurance build, with 4 Charm for Lone Wanderer and Attack Dog, and 2 Intelligence for Medic. Melee weapons only, no VATS, constantly drunk or tanked up on Chems, no companions (except Dogmeat), completely ignoring things like lock picking and hacking. I think it might be a fun build.
Anyone got any similar plans brewing?
P.S. Please don't bring up sleep saving and all that.