Ok, so we know that the protagonist is a war veteran. We also know that after you emerge from the vault you are able to almost immediately (it shows level 2 on the Xbox demo) get into some power armor. This leads me to assume that while in the military you have previously had power armor training. If that is the case, perhaps you are needed to help with the citizens in panic at the vault entrance and are asked to get into some power armor. This probably would allow you to survive the initial blast and give you a chance to descend into the vault. Its from there that we continue with the cryo sleep assumption until you awaken 200 years later. Of course the other viable option in my head is that you are already inside of a cryo sleep tube about to be lowered into the vault as the bombs go off. Or, one final guess would be that the initial blast is too far away to do harm initially... instead only looks bad due to the shock wave.
One additional thought about the cryo sleep scenario. What if the cryo beds are set to open once every year. This would perhaps explain why he wonders if others are still alive... but I don't expect family to be one of those. Perhaps other NPC's though that helped with the initial cryo sleep. (although I am also completely aware that Todd says 'you emerge as the sole survivor of vault 111)
Thoughts?