I would love to see a High Rock game personally. It does feel too much like Skyrim, but I think it and High Rock, being human provinces, have a good chance of better exploring their cultures and new unique gameplay mechanics. For example, High Rock's various Albalic nations, such as the Witch-Kings of Normar, the Horse-Tribes of the Bjoulsae, the Bretons of Wayrest, Camlorn and Daggerfall, and of course the Reachmen and tribes of the West Reach. Being as divided as it is, it could be a fascinating game, especially if we see the Empire collapse even further, who knows what the ramifications of that would be?
Daggerfall - the provincial capital of High Rock, along with its vassal Camlorn, would probably be under loose Imperial control, forming a sort of "West Empire" due to the loss of a direct land connection. Skyrim's war should have a victor, instead the war causing a rift in the province, splitting it into east and west as it was during the Second Era. The Stormcloak Rebellion failed in ridding Skyrim of the Empire, but seceded in its purpose by the Thalmor - weakening the Empire. But, due to Ulfric's death, which's exact nature I think should not be given, the Rebellion fractures, and the west is dealing with the Reachmen.
Because of the lack of Imperial supervision in the West Reach, it descends into war, the Nords making a move on Jehanna and Farrun, while Evermore contends with the Reachmen. Normar (Rivenspire) is also plunged into conflict. High Rock is perfect for a game for many ways: Todd Howard expressed an interest in revisiting High Rock, it is culturally linked to Skyrim, perhaps showing off the Nordic Albalics and their culture, it is a more magic-oriented setting, perhaps pathing the way for more magic-oriented settings like Alinor, lots of court politics and back-stabbing, and of course you also have the Direnni tower.
But I do think that BGS needs a more "different" setting before they venture back to into the human lands. A Valenwood or Black Marsh game would certainly be fresh, allowing them to return to the human lands with fresh new ideas and new ways to present Hammerfell or High Rock. If and when they make a full High Rock game, I don't want to see an ESO High Rock, I want to see High Rock is Cool. I would want to see every culture of High Rock Alt-Bal has to offer.