I'm currently doing a playthrough of Fallout 3 and I noticed something that may or may not have something to do with Fallout 4's protagonist coming out of cryo stasis and Vault 111 opening up. I have no idea if this idea has already been raised, my apologies if it has.
If you access Vault 101's Overseer's computer terminal during or after the quest Trouble on the Homefront, you can find some new entries. By new I mean since you left Vault 101 at the beginning of the game. One is called "External Contact Report". I'll type it out here:
I think this tells us a few things:
1. The Enclave knows about the existence of vaults on the East Coast.
2. The Enclave knows the location of Vault 101, probably of every vault on the East Coast.
3. They have records of entry passwords.
4. They have access to a governmental Vault-Tec frequency that allows them to communicate with the Overseer.
5. They are actively trying to get into the vaults.
Now them trying to access Vault 101 happens in 2277, since the record appears only after you've escaped and returned to the vault. By this date a fully functional vault is a rarity, most vault communities have collapsed by accident or on purpose as part of the Vault-Tec experiments. The only functional vaults at this time (in the DC area) are Vault 101 and Vault 112. Vault 112 is useless to the Enclave, the population there would never be able to exit the loungers alive. But Vault 101's population is intact, and holds the pure breed humans the Enclave wants in their ranks, unaffected by radiation. As far as the Enclave knows, at least.
The same thing could be said for Vault 111. The people there are possibly all cryogenically frozen and among the purest breed of humans in the Wasteland.
So how could they get into Vault 111 when they couldn't access Vault 101? During Trouble on the Homefront Amata will have changed the vault door password to "Amata". If she knows how to change the password, the Overseer must know as well. The Overseer actively tries to keep people out (and in) so it's very likely he has changed the password himself to make sure no one would enter. Thus rendering the Enclave's password records useless. The same thing most likely happened with Vault 112. Dr Braun did not want to be disturbed and he most definitely didn't want the government snooping around his vault. So he probably changed the password as well.
I think this may be different in the case of Vault 111. I think (I'm not sure of course) that everyone in that vault went into stasis after the bombs dropped. I don't think there have been people walking around that vault in the 200 years after the war while the protagonist is in stasis. Now if that is true that could mean they always intended to be rescued. They may have sealed themselves in the vault and put themselves into stasis to wait for the government to come in and wake them up when it was safe to go out. To that end they may have never changed the password, otherwise there would be no way for Vault-Tec or the government to reach them.
Thus the Enclave, freshly relocated to the East Coast, goes by every vault to look for pure-breed humans. They access Vault 111 with their password and wake up the inhabitants. If they have records of the different purpose and experimentation within each vault they could have very well given Vault 101 and Vault 111 priority, seeing as they seem to be two of the few vaults that actually tried to preserve human life. They wasted no time trying to open up Vault 101 after they became active in DC, perhaps they did the same with Vault 111. According to Todd Howard the Fallout 4 protagonist emerges from the vault 200 years after the bombs dropped, the Enclave became active in the DC area in 2077 - exactly 200 years later.
Sounds reasonable? Sounds like I'm mad? Please let me know what you think!