This mode is all about micromanagement and efficiency (from what I can tell) that being said the only 2 SPECIALS that have an accumulative bonus are END and INT (HP + XP/A) That being said I will go for them along with Idiot Savant at start and build up my charisma from there to farm xp to level 10 before I even leave Red Rocket.
My perks to aim for are Settlement management, 2 crafting perks, Medic, Resistances