In my http://www.gamesas.com/topic/1526198-two-nuclear-detonations thread, I proposed that rather than a single nuclear detonation, there were in fact two. After carefully re-anolysing some of the evidence, I can confidently say that I was actually wrong. There were not two nuclear detonations in the Greater Boston Area.
There were actually three.
Look again at https://www.youtube.com/watch?v=D5esyZPt5Jo&feature=youtu.be&t=4m45s image from the concept art. Notice how the area immediately around the crater is bare of any trees or buildings, but a short distance away, everything seems to be pretty much 'intact'. To the right, we can see the Bunker Hill Monument, and to the left we see a large cluster of 'unaffected' buildings, including Harvard and MIT.
So how then do we explain the extent and nature of the damage to buildings in the foreground?
The answer is that a third missile successfully detonated. But this time it was in the sea, specifically in the area East of the Boston Harbor Hotel, between the hotel itself and the airport. If we look at https://youtu.be/D5esyZPt5Jo?t=4m55s image from the concept art, we can actually see the explosion in Lincoln on the far left, and the one in Prospect Hill in the centre. There is also a third detonation visible on the far right, but it is much lower down compared to the other two, which would suggest an underwater detonation.
Now listen again to what Todd says about the Glowing Sea in https://youtu.be/DqQqeEgWb7Q?t=5m32s interview. At 5:32 he says:
"The other thing that people really need to know, we kind of hint at it in the trailer and the other footage, is that there is different weather. So, you'll see a couple of shots where it looks more like Fallout 3, where it's kind of blasted, and that... We actually have a part of the world we call the Glowing Sea, which is where the bomb falls. So, we wanted to vary, as opposed to just being one node. So there is a section of the map where the bomb fell, and that, that looks more like your classic Fallout 3 wasteland, but even more so. And then we have, we have a new weather system for this one so that, the storms from the Glowing Sea, these radiation storms, can flare up and then blow through the world. And, when the lightning goes off you get irradiated. That creates a very, a very post-apocalyptic look. So having that, having that change whilst you're playing the game is really important to us. And so, then there's rain and other things as well."
If you extract the sentences I have highlighted in bold, he seems to be talking about two different things. Firstly, the areas of the wasteland that 'look like Fallout 3' due to the lack of colour and their proximity to the land-based blast sites. And then he talks about 'the Glowing Sea', complete with radiation storms. Now look at https://youtu.be/D5esyZPt5Jo?t=4m50s image at 4:50, in which we can see many of the same buildings in the previous image, but this time a little closer. Notice that they all appear to have taken a great deal of damage considering how far away they are from the previously mentioned crater. Also, notice the sea. It does appear to have something of a 'glow', and perhaps the extreme 'weather' we can see going on is the beginning of a radiation storm.
And so I believe not only that there were three separate detonations, but that the Glowing Sea is actually Boston Harbor.
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EDIT: important new information added below.
Okay guys, after a great deal of further investigation, I think I may have finally made something of a breakthrough. First, a question:
What would tie Boston Harbor to the Glowing Sea, radiation storms, a 2285 start date, the design of vault 111, and the start of the great war? Well, you may wan't to consider the following:
On the morning of 23rd October 2077, a Chinese Super-Sub (seen https://youtu.be/D5esyZPt5Jo?t=4m27s at 4:27, current Chinese flag shown https://upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Flag_of_the_People) drifts into Boston Harbor after a 'mechanical failure'. The sub begins to descend, and eventually collides with a https://en.wikipedia.org/wiki/Submarine_mines_in_United_States_harbor_defense (shown https://youtu.be/D5esyZPt5Jo?t=3m40s at 3:40 on the right-hand side of the 'green' image). The detonation partially ruptures the hull, and a distress signal is immediately sent out. When the sub hits the bottom of the harbor, the resulting impact kills most of the remaining crew members, and also causes damage to the area surrounding the reactor core.
Meanwhile, the scrambled distress signal is received by the Chinese Military, and when contact with the sub is lost, it is assumed that this was a deliberate strike by the US. And so a non-nuclear missile is launched on an American target in retaliation, most likely another sub or a https://en.wikipedia.org/wiki/Destroyer. The US Military sees this as an act of war, and so they also retaliate. Before long, the situation escalates, and the result is a full-scale nuclear exchange involving China, the US, and the USSR.
Three nuclear warheads detonate in the Greater Boston area. First in Lincoln (seen from vault 111), then in Prospect Hill, and finally, in the harbor between the Boston Harbor Hotel and the airport. The detonation in the harbor throws up a massive volume of mud, water, and other debris at supersonic speed, destroying and partially vaporising many of the nearby buildings as seen in the foreground of https://www.youtube.com/watch?v=D5esyZPt5Jo&feature=youtu.be&t=4m45s image at 4:45. The underwater detonation also sends out a powerful electromagnetic pulse, causing http://navyadvancement.tpub.com/14325/css/14325_370.htm to the electrical systems inside the sub. The shockwave also tears a http://www.extremescience.com/deep-sea-vents.htm along the sea-bed, and the submarine ends up lodged partway down the fissure, leaking dangerous levels of radiation into the surrounding water.
The result of this incident is a https://en.wikipedia.org/wiki/Hydrothermal_vent on the sea-bed, which contains high levels of radiation (due to the ruptured core of the sub's nuclear reactor), a large pocket of superheated water, and a submarine hull that has been charged up like an enormous electromagnet by the EMP blast, and maintained by the reactor core. Whenever the temperature reaches a critical point, electrostatically charged and highly irradiated water is pushed up towards the surface, causing the surrounding water to 'glow'. The water vaporises as soon as it reaches surface level, and this vapour quickly gathers at high altitude to form electrostatic irradiated clouds. The clouds are blown inland, and as they move, radioactive lightning bolts are discharged, as described by Todd during the interview following the showcase.
As for the 2285 start date, an 8 year duration would allow more than enough time for the technology from project purity to be brought to other areas along the East Coast, including New York and the Commonwealth. This would explain the relatively 'clean' water we have seen in the showcase and concept art (apart, of course, from the radiated water being produced inside the hydrothermal vent).
And finally, the design of vault 111, as suggested in http://www.gamesas.com/topic/1523172-is-vault-111-built-like-a-submarine thread, now seems even more viable, as it ties in very closely with the incident described above.