It's the STARRY HEART OF THE WORLD! :bowdown:
More specifically, whilst Akavir is interesting, there's lots of problems I see with us visiting it. Most notably is simply that we don't know enough about it - Bethesda has a chance to take a totally alien location, like Morrowind (which was in Arena/Redguard's comic but was heavily lacking in any substance), and create a varied, exotic, and breathtaking world that will be loved for ages. On the flip side, they can mess up catastrophically, and many people will tell you that the main charm to Akavir is the fact we haven't been there in centuries and know so little about it - this gives it this strange, almost Romantic appeal. Again, Bethesda has the chance to make it really cool, but at the same time they could just tarnish our fantasies and turn it into something sub-par.
Secondly, we assume there's not much Tamrielic influence there. If you spend more time interacting with Ka Po'Tun and Monkey People than with actual man or mer, the game certainly starts to feel less and less like The Elder Scrolls. Even if, say, we play the "recently begun colonization by foreigners" card as with Vvardenfell, I think it'd just feel awkward and forced.
At this point in time I think the only way one could do justice to Akavir is to either leave it alone or to just make a portion of it present, in some awesome spiritual successor to The Elder Scrolls Adventures: Redguard.
Why not just make it an expansion, a la Shivering Isles? The two relatively modern Elder Scrolls have each had an expansion which kind of takes you out of the main provinces (Bloodmoon, Shivering Isles), although I suppose you could say Bloodmoon is still basically Tamriel. Anyhow, Shivering Isles definitely sets the precedent for taking the character to somewhere totally alien. It almost feels like a completely different game than Oblivion (except your character has the same skills, and can create the same potions, and carry over equipment from the main game).
So, they could potentially take you to some part of Akavir through a similar magic portal to how you got to the Madgod's Realm. Heck, instead of making it an expansion, maybe they have a game which is split between a kingdom in Akavir, and a province in Tamriel. Maybe there's things you can't accomplish in Tamriel before you first accomplish something in Akavir.
There's absolutely possibilities, it's just a matter of whether or not Bethesda/Zeni decide to try to go that route.
Actually, ever since I heard the rumor in Oblivion about the "Nerevarine going on an expedition to Akavir", it has suggested to me a strong possibility that gamesas might have something in mind for the future with Akavir (although, it might also have just been a way to explain why the almighty Nerevarine didn't show up to save the day, or possibly an in-lore way to save him/her from dieing when the Ministry of Justice crashed into Vivec City, although, honestly, I don't really expect the player character from a previous game to ever make an appearance in a future game - BUT, the future game could certainly include in the backstory/lore, some sort of events set into motion by the Nerevarine while he/she was in Akavir; since the Nerevarine was an Agent of Azura, it could be that he went to Akavir at the bidding of Azura, in order to pave the way for a future hero, or maybe another incarnation of the Nerevarine, I mean, if you can be re-incarnated once, why not twice).