Well, the issue is two fold:
1. The initial battle(s)
2. The aftermath
The Third Battle of the Castle
The Prydwen's destruction cripples the BoS right there in terms of morale and its ability to engage the Minutemen because that's their Vertibird deck and they just lost their God Leader. It's the equivalent of Hitler being blown up in WW2 along with the entire Luftwaffe. There's still plenty of military power but that's a kind of major blow.
What the Minutemen have to do next is survive the Brotherhood of Steel's counterattack. This is a bunch of paladins and knights attacking in revenge for Elder Maxson's death and the deaths of so many others. We don't know if this is meant to be all of the Brothers left in the Capital Wasteland but if not, then it's probably just the forces leftover at the airport (assuming they didn't all die in the crash of the Prydwen because that thing is going down Hindenburg style right on top of them).
In a realistic contest, it's going to be a horrifically epic fight as the Minutemen have fortified the Castle extremely well (presumably), have access to laser weapons, and in a "story" situation, you'd want all of your Companions there. Plus, as mentioned, artillery strikes me as one of the few things which could actually destroy Power Armor assuming the simple equation: Power Armor=Human Tank.
I can assume that, lore wise, the Sole Survivor would probably be wearing his suit himself. Going with a canonical military vet, he's also the only one of the Companions other than Danse (who wouldn't fight for them) who would be trained in its use anyway.
The Minutemen don't have to destroy the Brotherhood here but survive the Counterattack, which is very "doable" I think given you have a dozen hardened veterans (The Companions), however many Minutemen came out of retirement, all of their trainees, and whatever defenses erected on an automatic level. Assaulting a fortified position has historically been an enormous slog even for a well-prepared assault and this isn't going to be one. The Brotherhood of Steel WORSHIPED Elder Maxson and they're insane with anger, rage, and grief.
The Commonwealth versus the Eastern Brotherhood of Steel
BUT if they survive, then the BoS is broken in the Commonwealth. This doesn't mean the Minutemen could win a war against them, though. The Capital Wasteland has had 15 years to rebuild its forces and its entirely possible they may decide to make a full effort to return and destroy the Minutemen and avenge their leader. However, at the end of the day we have to wonder, "How big is the Eastern BoS after 15 years of rebuilding? How much is left after this attack? How much do they want a war?"
If the BOS want a war then, yes, the Sole Survivor is screwed and so is the Commonwealth.
If the Institute was evacuated and a Railroad allied ending was achieved, it may be a bit different.
The Institute will suddenly have to share its vast scientific knowledge with the Wastelanders and there's a near-infinite supply of tireless robot laborers with a loyalty to the Sole Survivor to help them prepare for the BoS. The Sole Survivor might be forced to go into hiding to avoid BoS vengeance. Even so, it's equally likely Maxson's death will create a power struggle.
But that's a story we're never likely to see.