Stepping on a trap or a mine when you are not full health, or getting blasted by a grenade that bounces off a wall and straight into your lap.

I dont really see any other chance that someone being careful could die in hardcoe mode except by explosives/traps

There will probably be moments during the story where you get swarmed by enemies.

i'd say its more likely someone goes away from the game for a while having forgotten to paused, comes back to find the character dead from dehydration....

Starving from lack of food or water

A Bullet..

HAHAHAHAHAHAHA.

Let's see when the game comes out. Like. Seriously. Unless you have it on easy, I really don't think any of us will last that long until we become gods (Which I hope won't happen).

mother in law visiting.

Damage and enemy difficulty is completely separate from hardcoe Mode.

You can play hardcoe Mode on Easy Difficulty if you like.

The ways that hardcoe Mode increases your chances of dying are two for even a careful player:

1) You get a crippled limb but do not have enough food or water to reach a doctor using fast travel (You cannot fast travel in hardcoe Mode if you do not have enough food and water for the trip.) The resulting slow slog across the map could conceivably get you killed.

2) The disadvantages and stat penalties give the enemies an advantage over you when you are already outgunned, resulting in your death as the blurred screen effect, etc. put you off your best game.

Even these can be overcome by stocking up on food and water. We want really know how dangerous hardcoe Mode makes the game until it is released and we see how common food and drink is.

hardcoe Mode DOES NOT make you weaker or the game "harder", its just a survival mechanic...
Edit- Ninja'd

This.

You cannot use fast travel in hardcoe mode?

Made me chuckle.

This is why they allow you to cannibalize or drink dirty toilet water

Yes you can, but the time that passes in game while you are fast traveling counts towards your hunger/thirst/sleep meter. That's what they were saying, and this is why I will fast travel to a location half-way to the location I want to go to so I can make sure all of that stuff is in check.

I think just going into combat with strong enemies before you're ready. The fact that DT now exists and that stimpaks heal over time in hardcoe, will combine to have you be destroyed by powerful creatures (I hope).

no, that's not what he said. If you fast travel your dehydrtion meter will drop due to the time elapsed in your trip. if you have no water and your dehydration meter is low you will not be able to fast travel to far away place.

*facepalm*

OT: You are just as likely to die from everything because hardcoe has nothing to do with difficulty.

I forgot Stimpacks heal over time :facepalm:

well I guess the bullet is really the most dangerous thing in the wasteland :gun:

Sawyer said that, yes, you can fast travel in hardcoe Mode.

However, the game WILL NOT LET YOU fast travel if it calculates that the time spent on the journey would kill you by depleting your meters. So if you try to fast travel with low meters, the game will basically say "No. Fast traveling will kill you right now. Go find food and try again."

I did not know this. I assumed that it would just initiate a death screen if you tried. I suppose that just works better anyway.

I hope different poisons will affect hunger and dehydration. mwahahaha.

And special stats of course.

The healing-over-time will likely do me in the most frequently. I don't pay much attention to my health, and often let it drop quite low before I tend to it.

Food and water were always easy to find in the Capitol Wasteland, but we'll have to see how that is in NV.

Like i said, cannibalism and dirty water is almost always an option to the food and water necessity.
however, you won't know what hit you when you step on a mine and the game suddenly says your character has been perma-deleted

hardcoe Mode doesn't have permanent death. It is just like regular mode in FO3 regarding death. If you die, the game loads up the last save you made and you keep going. This ain't Rogue or Wizardry from the 1980s here.

What?? are you kidding me? i thought hardcoe mode meant that you died forever, like in diablo 2