I've been having a lot of crashing issues. Basically I never went beyond character creation because the game would crash. Installing the latest Nvidia driver and Fallout 4's beta patch made no difference.
The only way I solved this was to forget about my monitor's native resolution of 2560x1440 and play at 1600x900. This way I played for hours, without a single crash!
I thought it would be less taxing on the graphics card if I played at 2560x1440 with no AA rather than at 1600x900 with full AA, but seems I was proved wrong.
I also thought my graphics card was future proof (especially with 4GB of Vram)... but it seems I was wrong here too!