Actually, on my current playthrough I DID side w/ The Powder gangers.
Usually I would help Ringo, yada yada yada.
This time I brought my wrath upon the unknowing citizens of GoodSprings, but after I kill sunny smiles and all the citizens I then turned my pistol on the gangers.
Got a WAY better pay out killing everyone than simply siding with one or the other.
Really the only reason I wiped them from existence was the fact that GoodSprings really has nothing to offer after that first quest, plus it only affected my rep in GoodSprings, no where else.
So I may be "villanized" but by who? A building? There's no one left to hate me.... I killed em all