Yes, substantive development predicated on the ashes of the old world.
New Vegas pondered what it would be like to not just have warring tribes, but nascent states (in the form of the Legion, House, and NCR).
That's what I'm hoping for (approximately) in Fallout 4 with the institute, not only can it ponder the possibility of a new state and the recrudescence of humanity but technology's place within it.
Ultimately what's the best ideology for a recrudescent human race, and what's the institutes own ethos/interpretation?
The canvas has been wiped clean for the the most powerful individuals, institutions, and factions of post-apocalyptic America and it's about time for someone to paint the future.
I'm not antipathetic to ethical debates about the nature of humanity and what distinguishes us (if at all from machines), but another debate about the ethics of Androids assimilating into society is banol and it wasn't the most impelling story in the replicated man quest either (which offered up many of the platitudes of such a debate). 
Technology in such a pugnacious society offers a profusion of intriguing ethical debates,whether it should be limited for the greater good,or if this would be a violation of freedom; what policies should be passed and contingencies offered to prevent annihilation again.
Can technology be used to assuage our lust for war, or will it only ever aggrandize one's ability to destroy another (such as the great war)?
What I don't want is the same argument, about the same technology (androids) with the same pleas and denials made.It can be phrased plainly, I don't want the 'replicated man 2'.