I might be clueless but there isn't much to confirm about the game by judging the trailer only.
Like everyone, i am a bit worried about the very possibility of a voiced protagonist, but this isn't confirmed yet.
There might be no voice, or just narration voice in some limited segment, by having the protagonist narrates instead of Ron Perlmann.
We just don't know yet, and i doubt even them would go to such low level.
I am also worried that the dog might be a dogmeat companion, but this isn't confirmed yet. We don't know if there will be a dog, if that dog will be a companion or if it will be called Dogmeat. I hope not, at least for the last two factors.
It seems there is more people in settlements, and more advanced technologies in those settlement. It seems reassuring after the mess they created with Fo3, which seemed like the bombs only fell a few years before, and in which you could call a town while there is only 1-2 people.
It also seems that they didn't spent too much time improving those useless polygons, which can lead a pretty optimist mind to consider that they might have spent that valuable time improving things that were lacking in Fo3, like writting, Choices & Consequences, consistency, RPG features, challenge, non-linearity, grey morality, mind-blowing dilemmas etc... One can still hope...
Although, considering the Fo3 experience, i will wait some legit non-affiliated reviews to form an opinion and consider getting it.