So it should have less content and more empty wasteland?
I'm finding it hard to articulate my thoughts on this!
Ok, Moira sends you to get some mines, you don't know about the sniper.
A small boy runs up to you yelling about monsters, you don't know what they are, where they came from!
You stumble upon tapes detailing the ghoulification of a man.
New Vegas - "hold up, theres deathclaws everywhere up here"
"Don't go into primm, theres escaped convicts from NCRCF"
The only quest I truly enjoyed was http://fallout.wikia.com/wiki/There_Stands_the_Grass