Let's see. I don't use:

Big Guns. Too heavy and awkward. I make an exception for the occasional use of the Fat Man and the Tesla Cannon. (I love blowing up the bus behind GNR)
Mines. All they're good for to me is the money I can make selling them. Though the idea of using them to farm for Raiders does intrigue me.
Companions. Mess up mojo, definitely. Most of them have no clue about Stealth. I make an exception for Dogmeat 'cause I like dogs and he's cute.
Gauss Rifle. Can't repair it by myself. Peesacrap.
Melee Weapons. Beyond using a bat or sword to squish 'roaches, I don't bother.
Power Armor. Eh. Just don't like it. I like outfitting my merchants with it, though.
Chinese Pistol. Most worthless gun on the list.
36 Cal. Pistol. Second most worthless gun on the list.

Apart from Bottlecap Mines and Nuka Grenades I don't use the workbench weapons, I'm just too lazy.

Yao Guai Slayer: Use the Gary 23 glitch and you can get an indestructible Gauss Rifle :flamethrower:

Ehm, there is no 36 Cal pistol Yao Guai Slayer


But for me, I never use Enclave or Enclave used power armor, dont like the effects. That, and the T51B Has only + effects, and is indestructible (Winterized Version)

I never used mines before I modded up the game to be more difficult and with scarcer ammo.

I still almost never use any drugs other than radaway, and rad-x for water areas. And stimpaks.

Any chemicals beside radaway, rad-x and stimpacks
Most big guns
Mines
Unarmed combat
Companions
Rarely use power armour
that repellent stick Moira gave me

Hmmm. There is so much that I don't use that it's probably easier to say what I do use, but I'll try:

No chems, except for Stimpacks, Radaway/Rad-X and the very occasional Med-X, Jet or Psycho
No 'Nades (I can't throw them very well)
No heavy armors, including Power Armor.
No Big Guns (the Fat Man at GNR plaza is about the only exception I can think of, but I sell it soon thereafter)
Almost no handguns (Scoped .44 being the notable exception)
Almost no Energy Weapons, mostly because that skill lags behind
No Shotguns. I'll keep the Terrible Shotgun if I get it (I usually don't), but the rest get sold
Almost no Melee Weapons
No Companions (Fawkes and/or Dogmeat get left at home)
No Beer/Booze/Quantum

'Course because of not using these, I'm usually never hurting for caps, but ammo for the stuff I do use can be a chore

Chems - I always have tons of chems with me but I never remember to use them, except for radaway, rad-x and stimpaks.

Melee or Unarmed weapons - I just don't like this type of combat, though I'll occasionally use a melee weapon to save ammo, mostly during the first levels.

Galaxy News Radio (and radio stations in general) - I used to listen to the radio during my first playthrough, but I eventually got tired of it. Now I prefer the eerie silence of the Wasteland.

Big Guns - My last character was a big gun guy, but most of my characters prefer small guns and energy weapons.

Probably the only thing I never use is small guns, or drugs. I'll take an occasional whiskey break, but thats about it.

I started to deliberately make use of the fatman because it was one those guns that I never used on so many early playthroughs. Nowdays it's the alien blaster, just nice to know it's there in case I need to come back for a 'bigger' gun!

Some perks rarely get used like animal friend L2 and sandman which could be useful/fun perks to use once in a while, I just never seem to get around to trying them out.

I crossed out the ones I do use, but don't use the others. Also Lincoln's Repeater, T51-b power armor, pre-war clothing, including hats, baseball cap and all headwear (except Lucky Shades and headwrap), vault suit, armored vault suit, radiation suit, 10mm pistol, hunting rifle, BB gun, combat shotgun, switchblade, Firelance, Alien Blaster, Laser Pistol, Laser Rifle, pulse mine, pool cue, sledgehammer, super sledge, shovel, auto axe, ripper, chinese sword, power fist, Clover, Jericho, Dogmeat, Bloody Mess perk, Here & Now perk, Nerd Rage perk (and a bunch of others), Nuka Cola Machine - it just never works for me. It swallows my Nuka Colas and remains empty, and as it takes up too much room I just don't bother with it.

I think that's it. It's all I can think of, anyway. I've tried them once, maybe, but decided I didn't like them/they didn't suit my characters. In the case of some of the weapons they just sound bad (ripper, power fist, combat shotgun)
The unique weapons and armor I just toss in a locker in my house. I can't sell them, must collect the different things even if I never use them.

Just to be different I should make a character that only uses those things. But, I'm sure he/she will suffer from the problem a few of my characters have had - can't get past level 4 because I get bored with them.

Edit: Missed a few after reading previous posts.

10 mm pistols/ smg, except in the early game when I don't have much ammo for other guns or high enough small guns skill to where I'm not wasting bullets.
Power armor, it's just too bulky and doesn't have much of a benefit
Companions, it's like running around with kids with ADD
Energy weapons, too scarce early on, and I never build up my skill
Any of the weaker H2H or melee weapons, except on a couple characters I created specificly for that type of combat
The juke box, I don't listen to the game music anyway
Any armor besides combat armor and its upgraded versions, everything else just isn't that good

All that fancy unique clothes i got from Autumn and the scribes, because I can't repair it.
It's the same with the gauss-rifle. I never use alien power cells either. I hate when some content is limited.

And bent tin cans. I don't use them, nono... :nope:

there are a while lot of things i never use in the game. same as most people, no chems apart from stimpaks & radaway. weapons that i cant repair on my own. pre war clothes, what is the point like? would be different if some of the outfits actually looked decent. any sort of food at all, collect sugar bombs for murphy just. stealth boys/chinese stealth armor, ruins the game. all power armor except for the enclave hellfire armor, take that if i take a wee trip to point lookout & because its the best looking in the game. practially all small guns & melee weapons.

I don't use Unarmed, Mines or Big guns with the execption of the Missle Launcher and the Fatman. No need for them, why use a mini gun when a Chinese Assault Rifle is more accurate and deadly.

You don't use the rock-it-launcher? Shame on you!

OMG I'm revealed

But that scrapgun just ain't sixy enough to me B)

What isn't sixy about making a deathclaw's head explode with a cutting board? :laugh:

I do not eat food, as it will give you rads. Thanks to that I do not have to use toilets, also saving me from rads.

I do not use stealth boys. Not because I do not want to, I just forget I have them. Or I save them for when I really need them, and then never wind up using them because by the time I find out I really need it, it is too late.

I do not use Lincoln's Repeater. It is just too darn slow to reload. No wonder Lincoln is dead...

That′s not sixy. That's screwed.

I like it :nod:

Theres something you don't hear every day.


An interesting fact, beer can keep you hydrated better then watter. Though obviously too much and then we have other problems.

(Chinese) Assault Rifles... Mainly because they make an annoying noise when being fired & that its just flat boring using them.

You sure 'bout that?

I don't use any of the chems (besides stimpaks obviously) or explosive weapons.

They're just not my thing.

I do not use:

-any chems other than the occasional anti-rad med or stimpack.
-most Small Guns or Energy Weapons
-Mines, although I do use grenades occasionally
-lower-grade armors, except while in the Pitt since I always go in there with nothing other than what Wernher gives me
-melee or unarmed weapons (see above re: the Pitt)
-food for healing, since it's not worth it
-most custom weapons, although I do have a character who uses them exclusively for added challenge
-the Chinese Stealth Armor (the thing is stupidly overpowered IMO)
-most unique weapons, since I feel many of them are too powerful compared to the normal version

I have made a number of modifications to my game, so some of the items on the list would be essential to other folks.

Food, water and beds to heal myself. I play with my own hardcoe mode where I must use stimpaks or doctors to heal, and I must use doctors to heal crippled limbs.