That yao guai wasn't there to maul me in the previous quicksave. Neither was that giant radscorpion. I hate them! When I get the animal friend perk, it will not apply to giant radscorpions. Out of ammo for other guns, how did I fare against a GRscorpion with a sawed-off shotgun - Miserably, they laugh at pellets. I think that in the vanilla game, some script is following the player around and sometimes spawning things at medium distance away from the player.
If this is true, then forget about a dead is dead playthrough after L8. FNV didn't do this, I was always confident of what was ahead until the hit squads began to spawn. Am I imagining things? Also in Skyrim, I have seen things spawn right at my location.