One might be made possible by Crytek and might set this game apart in a new way. (as far as I know)
The other is up to the the mod-community.
1. Now that Crysis is also available for consoles let us have mixed mp. Xbox PlayStation and PC gamers all mixed in one multiplayer. The console-players of-course may use auto-aim while PC-user may not. Is there any game that offers this already? I don't think so.
2. Make some older great games relive as a Crysis 2 Mod. (of-course with the weapons originally used and no Nano-suit). For example Doom, or the standard maps from Wolfenstein (return to castle / ET) or maybe event the house of Lara Croft in TR2. Maybe the start-area from Postal 1 (yes one). When doing so it should also be as simple as in the original but with the graphics and physics from cryengine 3. Not tree's where they do not belong (because they look so cool) and all of these extra stuff that make new game so.. crowded.