One thing I do think Bethesda needs to really look at it how ridiculous things are getting in terms of major cities not really being destroyed. Between Fallout, Fallout 2, Fallout Tactics, Fallout 3, and Fallout New Vegas we've seen the following major cities:
LA - pretty much destroyed as presented in Fallout 1
San Francisco - not destroyed according to Fallout 2
Reno - not destroyed according to Fallout 2
Chicago - apparently not destroyed based on the cutscene at the beginning of Tactics
St. Louis - mostly destroyed according to Tactics
Denver - damaged but not destroyed according to design documents for Fallout3/Van Buren (not necessarily canon)
Washington DC - damaged but not destroyed considering major buildings and monuments are mostly still standing 200 years later in Fallout 3
Pittsburgh - damaged but not destroyed in Fallout 3/The Pitt DLC
Vegas - somehow the nukes avoided this place as well as we see in Fallout New Vegas
It's honestly a bit ridiculous. Especially when you consider that if you talk to House about it in New Vegas he claims that city was targeted by some absurd number of nukes (77!) that he mostly dealt with. Makes me think nukes in the Fallout universe are all suitcase-sized equivalents.