I've been playing the game since release and have thought about it as a whole.
The game feels like it was designed by several different designers. Is this supposed to be a serious game? A funny game? A silly game?
It's all of them and the game just isn't memorable with all these combinations. The world as a whole makes little coherent sense.
One moment you're bombing mirelurks using all these ridiculous weapons with the CHI CHING noise every 5 seconds, then two minutes later you're listening to a certain sad Chinese captain that wants to go home. One hour later you're helping robots with funny hats get a wooden ship to fly. It feels like the world is a random sandbox with isolated stories here and there.
Those moments are fun in isolation and I greatly enjoyed the submarine and Constitution quests.
The game just lacks a significant, central theme or atmosphere. Fallout 3 had a somber atmosphere of a destroyed world where everything is destroyed and bad, so it's our job to fix it (though it did have it problems).
Even though I found NV to be better, I see screenshots like this and I can see myself playing F3 as a whole again.
https://bbot.org/blog-images/fallout3-2-moved.jpg
For Fallout 4, there is just no drive or reason to play the game as a whole again. Sure, I'd love to play the Constitution quest again, but the majority of the game as a whole?
Sure, the game has many improvements over the past games. Better graphics, gameplay, more choices compared to F3, but it just doesn't have that innovation or quality that F3 and Skyrim had. I started a new character but it feels liek I'm continuing the first character.