I have recently built a new PC using the Windows 7 operating system. I cannot get FO3 to work, as it crashes very quickly on startup.
I have no special audio card, and I honestly don't know my video cards name. I believe the problem lies either in Windows 7 or my mod order.
I have tried the following fixes:
-The HWThread fix in the .ini
-Downloading d3d9
-Patching it, it launches it then it crashes

*I have FOSE installed

My Mod Order:

CRAFT.esm
CALIBR.esm
EVE.esm
EWE Energy Weapons Enhanced.esm
FO3 Wanderers Edition - Main File.esm
Mart's Mutant Mod.esm
Fallout3.esm
FO3 Wanderers Edition - Main File.esp
FO3 Wanderers Edition - Followers Enhanced.esp
WeaponModKits.esp
WeaponModKits - FWE Master Release.esp
EVE - FWE Master Release (Follower Enhanced).esp
EVE - FWE with WeaponModKits.esp
Mart's Mutant Mod - Feral Ghoul Rampage.esp
Mart's Mutant Mod - Increased Spawns.esp
Mart's Mutant Mod - Zones Respawn.esp
Mart's Mutant Mod - Hunting & Looting.esp
Mart's Mutant Mod - Natural Selection.esp
Mart's Mutant Mod - Dynamic Player Scaling.esp
Mart's Mutant Mod - FWE Master Release.esp
EWE Load Order Fix.esp
Fellout-Full.esp
Total active plugins: 22
Total plugins: 68

I recently started this post on PC issues but got no response, so I posted it here.

For Windows 7, I would install it to somewhere outside of 'Program Files', like c:\fallout3. Start there if you haven't done so.
Not sure if EWE and EVE are compatible either. Don't they change the same things?

Apparently they are compatible. The readme says to deactivate EVE.esm and EVE.esp from your mod list and use the EVE.esm that's included in EWE. I don't know I've never used both before.

And you load order is in terrible shape. I would highly suggest downloading http://www.fallout3nexus.com/downloads/file.php?id=10193 to organize your load order properly. And with the mods you're planning on using you'll want to at least create a Merged Patch. This must be done with http://www.fallout3nexus.com/downloads/file.php?id=637. Also http://www.fallout3nexus.com/downloads/file.php?id=8629 a manual for FO3Edit so you can easily learn how to create a merged patch and even clean mods you plan on using.

Lastly you'll be required to set Archive Invalidation. This tells the game to use "new" resources from the data files. This can simply be done with http://www.fallout3nexus.com/downloads/file.php?id=944.