I love the idea of Dead is Dead and have played some games with it. I have never tried to play any Fallout games with DiD and I find the concept interesting in Elder scrolls but a bit "lacking" because you are often killed very unnexpectedly and sudden in ES where it is very hard to predict. Often you are fighting some enemies as usual having a "fair" fight and then some super powerful mage jumps in and shoots a thunderbolt at you from nowhere and you are dead instantly.
When not playing DiD I like to crank up the difficulty as high as possible though, and this is what I have been thinking of doing with Fallout 4 at first. That is a "normal" playstyle without DiD but on the hardest difficulty. But then I remember how that feelt extremely lackluster in the previous Fallout games because all it did was increase the damage you got and decreased the damage you gave enemies. So a satisfying shootgun blast to the head to someone that is supposed to blow their head off now just makes them flinsh. It feelt so unrealistic.
So I am thinking if DiD on normal diffuclty could be a good middleground to still have the game be challanging and nerving, but at the same time keep it feeling more realistic then the damage values on the highest difficulty. Any thoughts on this and how are you going to play? Anyone played DiD on previous Fallout games (or ES if you have not done it in Fallout) and what difficulty do you prefer for it?