In FO2, it was revealed that FEV was developed in a lab in Mariposa, CA. There they had started to do human modification experiments, hoping to create a supersoldier. Then the war came. In FO3, the Supermutants had a supply of FEV in Vault 87 and were augmenting their ranks by snatching humans and subjecting them to the FEV alteration process. Connecting the two FOs, one can conclude that FEV had been widely distributed just before the world went BOOM. And that more than likely Supermutants, products of the FEV program, know where those FEV sites are located and as in FO3, continue to create more Supermutants to swell their ranks.