1 - Voiced protagonist really hurts the freedom of having any sort of character you want, can be very immersion breaking if you character does not at all fit with the voice
2 - Dialogue weel and dialogue in general feels very "dumbed downed"
3 - Does not seem to be as much freedom in general in quests etc, very hard to play anything else then a goodie goodie father. You are either very good or just good but a little rude, no room really to play an evil character. The perks like cannibalism and idiot savant further clash with everything else the game is now since it does not fit at all with the premade character you have been given.
4 - While I actually think the story is quite good it does not work well to have such a focused main quest with a free rpg since the urgency in it makes it feel strange to do anything else if you are trying to play logical and you are constantly reminded of the main quest.
5 - Could have made a more interesting survival diff with more realistic damage instead of just bullet spoonge, look at games like Deus Ex for good example. Would also been better with more immersion elements in this mode, like need for sleep and food, more realistic carry weight, more dangerous radiation, etc etc.
6 - The settlement building part in general feels a bit immersion breaking to me, the way you just create things out of thin air and have a happiness meter etc etc makes it feel very "gamey". It makes the rest of the world seem less real to me.
7 - Seems to be lot more in your face fireworks for everything you do like in many other games. When you get a charm test right you get a big sound effect and a thumbs up from the pipboy character, it all feels very "gamey" again and less about immersion.
8 - Not a fan that you get a message about if your companion liked or disliked something you said in a dialogue, feels "gamey" again. Would be better if they commented on what you said after or in the middle of the dialogue and you would have to gauge if they disliked or liked something by what they said.
9 - Still not possible to sleep in an "owned" bed even after you have killed and looted a whole village.
10 - Feels very hand holding in the way companions can't die and there also seems to be many protected NPC characters in general.