How would you guys feel about a New Vegas style (Fallout 4 engine with some borrowed assets) Fallout game set in the Midwest like Utah or Idaho. The technology would be less advanced with weapons like spears and bows being standard, home-made or salvaged firearms being mid-level weapons, and functional plasma rifles and combat rifles being the equivalent of Fat Mans and Gatling Lasers in Fallout 3 or 4.
The story of the game could be about the player character trying to save his tribe from conquest by Caesar's Legion. We could finally explore places like Dogtown (Denver) and Flagstaff (Legion "capital"). There could be super mutants left from the Master's Army but overall less radiation and more wilderness.