I clicked the first link listed and I am looking at it. Will any of this benefit an AMD user?
Most of the tweaks have nothing to do with a particular GPU architecture, they're about getting better quality or performance from any card. Things like the ugrid settings, AA, FXAA, etc. I think there were 1-2 pages about NVIDIA, but most of the guide is architecture neutral. There were great screenshot comparisons of all of the settings, too.
There are a couple of pages at the end for ini, tweaks, such as how to change your map settings, etc. I've seen nearly all of the settings he talks about before, but he explains everything very well, has a lot of screenshot comparisons, and IIRC has benchmarks comparing the effect of different settings.
It's definitely worth reading through when it's back up.
BTW, semi-interesting trivia: I've been holding back on modding the game, but over the last couple of days started using SKSE, a fair number of textures, and then reconfigured the ini using the tweak guide. I started getting frequent CTDs, and the purple texture issue. I'm wondering if reconfiguring the ini is a large part of the CTDs that everyone talks about (I've had a few before, but much less often). So then I installed the 4GB Skyrim mod, and now the game looks better than ever and is stable again.