Against humanoids, greatswords have the most entertaining killcams IMO.
However, if by 'specialize' you mean putting perk points into Deep Wounds, Skullcrusher or the battleaxe one whose name I forget - sadly, they're not worth very much. I think all of those perks work out to something like an extra 10 points of damage, even when you invest in all 3 levels.
If you've got lots of perk points to spare, I guess it couldn't hurt. I've taken Deep Wounds on one of my characters in the past, because IIRC that one also affects stagger chance.